Article
  • Fabrication of Tubular Scaffolds with Aligned Fibrous Structures Containing Cells within Pockets Using Electrohydrodynamic Methods

  • Inseong Choi*, **, Guk Young Ahn*, **, Dong-Hyun Paik*, **, and Sung-Wook Choi*, **,†

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea

  • 전기유체역학적 기법을 이용한 정렬된 섬유구조체를 갖는 세포 함유 스캐폴드 제조

  • 최인성*, ** · 안국영*, ** · 백동현*, ** · 최성욱*, **,†

  • *가톨릭대학교 바이오메디컬화학공학과, **가톨릭대학교 생명공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Fibrous tubular scaffolds with cells in pockets were fabricated by a combination of electrospinning and electrospraying methods. Cell dispersions were electrosprayed onto a rotating drum while a polymer solution was electrospun at the same time for the production of the fibrous structure. The electrospun fibers were aligned onto the rotating drum using conductive wires, creating pockets with cells present within the scaffold. The thickness of the scaffold and the number of the cells were controlled by varying the processing time. These scaffolds could be potnetially utilized for the tissue engineering of nerve, bone, and blood vessels.


전기방사 및 전기분무의 두 가지 전기유체역학적 기법을 이용하여 포켓 내에 세포가 함입되어 있고 정렬된 섬유구조체를 갖는 관형 스캐폴드를 제조하였다. 스캐폴드 제조를 위해 분산액을 회전 드럼에 전기 분무하는 동시에 섬유구조를 형성하기 위해 고분자 용액을 동시에 전기방사하였으며, 전도성 와이어를 통해 정렬된 구조의 스캐폴드가 형성되고, 전기분무를 통해 섬유구조체 내부에 존재하는 포켓에 세포를 함입시켰다. 제조된 스캐폴드의 두께 및 세포 농도는 분무와 방사시간을 통해 조절되었으며 해당 스캐폴드 제조기술은 신경, 뼈 및 혈관의 조직재생에 활용할 수 있다.


Keywords: electrospray, electrospinning, fibrous structure, cell entrapment, scaffold.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2023 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2021; 45(6): 904-909

    Published online Nov 25, 2021

  • 10.7317/pk.2021.45.6.904
  • Received on Jun 29, 2021
  • Revised on Jul 30, 2021
  • Accepted on Aug 13, 2021

Correspondence to

  • Sung-Wook Choi

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu,
    Bucheon-si, Gyeonggi-do 14662, Korea

  • E-mail: choisw@catholic.ac.kr