Article
  • Fabrication of Starch-Lauric Acid Nanoparticles for Potential Tumor Therapy
  • Guk-Young Ahn, Inseong Choi, Tae Hoon Yun, and Sung-Wook Choi

  • Department of Biomedical Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, Korea

  • 잠재적 종양 치료를 위한 전분-라우르산 나노 입자의 제조
  • 안국영 · 최인성 · 윤태훈 · 최성욱

  • 가톨릭대학교 바이오메디컬화학공학과

Abstract

This manuscript reports on the fabrication of starch-lauric acid (St-LA) nanoparticles having potential cancer therapy. St-LA nanoparticles were fabricated by varying the amount of LA, and the optimized St-LA nanoparticles were found. In addition, it was confirmed that the St-LA nanoparticles were successfully fabricated through scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) analysis. In vitro, the St-LA nanoparticles showed cytotoxicity in A549 and Caco-2 cells but not NIH/3T3 cells. These results were confirmed by LIVE/DEAD staining and fluorescence imaging. Our next goal is to evaluate the St-LA nanoparticles containing various anticancer drugs through in vitro and in vivo studies. St-LA nanoparticles can potentially be applied to cancer chemotherapy.


라우르산의 양을 변화시킴으로써 잠재적인 암 요법을 갖는 전분-라우르산(starch-lauric acid; St-LA) 나노 입자를 제조하고 최적화된 St-LA 나노 입자를 발견하였다. 또한 주사 전자 현미경(SEM) 및 푸리에 변환 적외선 분광법(FTIR) 분석을 통해 St-LA 나노 입자가 성공적으로 제조되었음을 확인하였다. 세포 실험에서, St-LA 나노 입자는 A549 및 Caco-2 세포에서 세포 독성을 나타내지만 NIH/3T3 세포는 나타내지 않았음이 LIVE/DEAD 염색 및 형광 이미징에 의해 확인되었다. 따라서 St-LA 나노 입자는 잠재적으로 암 화학 요법에 적용될 수 있을 것으로 판단된다.


Keywords: lauric acid, nanoparticles, antitumor effect.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2018 Impact Factor : 0.500
  • Indexed in SCIE

This Article

  • 2021; 45(1): 62-67

    Published online Jan 25, 2021

  • 10.7317/pk.2021.45.1.62
  • Received on Jul 15, 2020
  • Revised on Aug 26, 2020
  • Accepted on Sep 9, 2020

Correspondence to

  • Sung-Wook Choi
  • Department of Biomedical Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, Korea

  • E-mail: choisw@catholic.ac.kr