This study examined the transdermal delivery of alendronate across hairless mouse skin. The effects of iontophoresis, perforation with a microneedle, and a combination of a microneedle pretreatment and iontophoresis were evaluated in vitro test. Hydrogel patches were polymerized by UV polymerization to supply a hydrogel patch to the iontophoretic transdermal drug delivery system. The alendronate content in the iontophoretic delivery patch was 5.0 mg/cm3. The amounts of alendronate that permeated across the hairless mouse skin when current densities of 0.25 and 0.50 mA/cm2 were supplied to the iontophoretic alendronate patch were 0.80±0.03 and 2.00±0.02 μg, respectively. After pretreatment with a microneedle, the amounts of alendronate that permeated across the hairless mouse skin increased to 70.65±0.37 and 162.23±0.40 μg, respectively. The biocompatibility of the iontophoretic alendronate patch was examined according to the international standardization organization 10993.

알렌드로네이트의 생체이용률을 높이고 경구복용시 발생하는 부작용을 해소하고자 경피약물전달시스템에 전기이온영동법, microneedle 등을 적용하여 in-vitro 시험 후 약물전달량을 HPLC-Flu를 이용하여 조사하였다. 전기이온영동시험을 위해 사용된 약물 패취는 UV중합법으로 합성하였으며, 이

Keywords: microneedle; iontophoresis; alendronate; transdermal drug delivery.